CB1 and CB2 Receptors

Our body’s Endocannabinoid System has two main receptors,  CB1 and CB2. These two receptors assist our bodies in everyday function and healing.

CB1 Receptors are in: the brain, central nervous system, spinal cord, neocortex, pyriform cortex, hippocampus, amygdala, cerebellum, brain stem, basal ganglia, olfactory bulb, thalamus, hypothalamus, pituitary, thyroid, upper airways, liver, adrenals, ovaries, uterus, testes, sperm cells, prostate, eyes, heart, stomach, pancreas, digestive tract, and bone.

CB2 Receptors are in: Eyes, heart, stomach, pancreas, digestive tract, bone, spleen, thymus, tonsils, and blood lymphocytes.

If a medical marijuana patient is deficient in CB1, a higher THC to CBD ratio is beneficial. Typically, if a person is CB1 deficient, neurological diseases may arise along with mental and emotional problems.

If a patient is deficient in CB2, a lower THC to CBD ratio is helpful. CB2 deficiency tends to cause a compromise in the immune system and has potential for chronic inflammation.

A common cannabinoid in food is (E)-BCP. (E)-BCP activates CB2 receptors. The phytocannabinoids CBD and CBN have a greater attraction to CB2 receptors while THC likes to interact with CB1 receptors.


This information is in reference to The Cannabis Health Index by Uwe Blesching, PhD. We hope this small outline helps you to better understand the Endocannabinoid receptors.